Spyre Therapeutics, Inc. (SYRE) — Biotechnology. Numbers-first dossier: valuation, distress risk, calibrated signal.

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Bid — × — AskUpdated Nov 9, 2026 · 4:00 PM ETVol 1.39M · 3-mo avg 1.21M

Spyre Therapeutics, Inc. (SYRE)

SYRESpyre Therapeutics, Inc.loading…
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QTick signal
-6net
0 bull / 5 bear factors · moderate
Bull 1 pts·Bear 7 pts30d
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Market context—Sector read · not on fileOKBalance sheet · Safe—Inflation-report days · not on fileOKCalm trading · sharp-drop risk 0/100 · Nov 9
$107.77
near a support level · Nov 9
$109–112
near a resistance level and the 52-week high · midpoint $110.64 · Nov 9
±$0.24
±0.2% up or down, priced by the options market
Golden cross
50-day average is above the 200-day — an uptrend
In line
96% of similar setups fell 10% or more within 3 months · 1.2× the usual rate · rating eased: at bottom zone (2/6 bottoming checks met)
Golden cross
50-day average is above the 200-day — an uptrend
Trading volume28% above normal1.28× its 20-day average
Past year's range$21.15 – $110.18lowest to highest price
From its peak65.8% belowpeak $319.04, highest since 2016
Gain vs. risk0.13 to 1$0.13 possible gain per $1 at risk
Plan fails below$96.39the setup is broken under this price
Options pressure point$55.00far from the price, likely stale options data
Momentum (RSI)69.6fires under 35 · fires near $77.14
Accounting warning signs1worth checking — see the list
Price vs. profitno profit to compare
Cash it generates-1.8%it used more cash than it made

Last session traded in line with its own normal, price up 4.9%. Over the last 20 sessions, 47% of the volume traded on days the stock closed lower.

Entry strategy · 10 triggers

0 of 5 aligned — not yet
RSI 14
●
69.6
fires under 35 · fires near $77.14
vs 50-day
●
$90.16
above the line · fires near $90.65
Bollinger
●
$76.45
no lower pierce · fires below the slider range
VWAP 20
●
$92.01
above the rolling VWAP · fires near $91.86
Entry level
●
$107.77
level below · fires near $108.80
Put wall
●
—
not on file
MACD
Context✓
+1.33
histogram above zero · rising
RVolStatic
1.28×
in line with its own normal
Short int.Static
15.4%
short interest below 20%
ATRStatic
$4.75
14-session average true range
A checklist, not odds on a return: 3 of 5 usable price conditions have to line up. RSI, the 50-day average and the Bollinger band move with the price you set; the 20-day average traded price, the entry level and the busiest put strike stay fixed. MACD, RVol, Short int. and ATR are context only — they never count toward the total.
See the full case→
Next earnings
2027-02-18
in 68 sessions
Next dividend
No indicated yield
no forward dividend on file