Spyre Therapeutics, Inc. (SYRE) — Biotechnology. Numbers-first dossier: valuation, distress risk, calibrated signal.

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Bid — × — AskUpdated Sep 25, 2026 · 12:00 AM ETVol 560.0K · 3-mo avg 1.21M

Spyre Therapeutics, Inc. (SYRE)

SYRESpyre Therapeutics, Inc.loading…
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QTick signal
0net
2 bull / 3 bear factors · balanced
Bull 5 pts·Bear 5 pts30d
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Market context—Sector read · not on fileOKBalance sheet · Safe—PCE inflation days · not on fileOKNeutral tape · 43/100 · as of 2026-09-25
Smart entry
$85.26
basis · pivot low + s1 · as of 2026-09-25
Target exit zone
$89–91
center $90.00 · basis · call wall + round · as of 2026-09-25
Implied move · 1 wk
±$7.96
9.3% · options-priced
Chart pattern
Golden cross
50d above 200d · but price is 12% below the 50-day — structure damaged
Pullback risk
In line
1.08× the norm · 85% saw a ≥10% dip · 63d · tape state: neutral · capped: at bottom zone (1/6 bottoming checks met)
Chart pattern
Golden cross
50d above 200d · but price is 12% below the 50-day — structure damaged
Volume vs its own 20-session average0.43×
52-week range$15.49 – $110.18
Below high since 2016-73.1% · $319.04 high
Risk / reward0.53 : 1
Plan stop$77.52
Max pain$95.00 options cluster
RSI 1436.0 fires under 35 · fires near $84.94
Forensic flags1 review
Earnings multiplen.m. — no profit expected
P/E vs its own pastnot on file
Free cash flow yield-2.3% · burning cash

Last session traded lighter than its own normal, price down 1.6%. Over the last 20 sessions, 57% of the volume traded on days the stock closed lower.

Entry strategy · 10 triggers

3 of 6 aligned — closing in
RSI 14
●
36.0
fires under 35 · fires near $84.94
vs 50-day
✓
$97.11
below the line
Bollinger
●
$85.59
no lower pierce · fires near $85.48
VWAP 20
✓
$89.50
below the rolling VWAP
Entry level
✓
$85.26
within 1% of model level
Put wall
●
$70.00
2026-10-16 expiry · chain of 2026-09-24
MACD
Context●
-0.21
below zero · still falling
RVolStatic
0.43×
lighter than its own normal
Short int.Static
14.6%
short interest below 20%
ATRStatic
$3.87
14-session average true range
A checklist, not odds on a return: 4 of 6 usable price conditions have to line up. RSI, the 50-day average and the Bollinger band move with the price you set; the 20-day average traded price, the entry level and the busiest put strike stay fixed. MACD, RVol, Short int. and ATR are context only — they never count toward the total.
See the full case→
Next earnings
2026-11-03
in 28 sessions
Next dividend
No indicated yield
no forward dividend on file