Ionis Pharmaceuticals, Inc. (IONS) — Biotechnology. Numbers-first dossier: valuation, distress risk, calibrated signal.

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IONSpeers & supply-chain relationships

IONS earnings history

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Bid — × — AskUpdated Nov 10, 2026 · 1:16 PM ETVol 3.52M · 3-mo avg 3.20M

Ionis Pharmaceuticals, Inc. (IONS)

IONSIonis Pharmaceuticals, Inc.loading…
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QTick signal
+7net
3 bull / 1 bear factors · moderate
Bull 9 pts·Bear 2 pts30d
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Market context—Sector read · not on fileCautionBalance sheet · Grey—Inflation-report days · not on fileRiskFalling sharply · sharp-drop risk 100/100 · was 81 on Nov 5 · Nov 90/6Bottom watch · 0 of 6 confirmations
$29.53
near the 52-week low and a support level · Nov 9
$45–46
near a heavy call-option level, the 50-day average and the 50-day average trade price · midpoint $45.33 · Nov 9
±$5.09
±17.4% up or down, priced by the options market
Death cross
50-day average is below the 200-day — a downtrend
Elevated
95% of similar setups fell 10% or more within 3 months · 1.2× the usual rate
Death cross
50-day average is below the 200-day — a downtrend
Trading volume444% above normal5.44× its 20-day average
Past year's range$29.23 – $86.74lowest to highest price
From its peak65.9% belowpeak $90.90, highest since 2015
Gain vs. risk3.24 to 1$3.24 possible gain per $1 at risk
Plan fails below$24.64the setup is broken under this price
Options pressure point$60.00far from the price, likely stale options data
Momentum (RSI)20.0oversold
Accounting warning signs1worth checking — see the list
Price vs. profitno profit to compare
Price vs. its own pastusual P/E 763.9×median of the last 5 years
Cash it generates-4.5%it used more cash than it made

Last session traded heavier than its own normal. Over the last 20 sessions, 72% of the volume traded on days the stock closed lower.

Entry strategy · 10 triggers

6 of 6 aligned — not yet
RSI 14
✓
20.0
oversold
vs 50-day
✓
$46.20
below the line
Bollinger
✓
$35.91
lower-band pierce
VWAP 20
✓
$39.39
below the rolling VWAP
Entry level
✓
$29.53
below the model level
Put wall
✓
$55.00
2026-11-20 expiry · chain of 2026-11-10
MACD
Context✓
+0.43
histogram above zero · rising
RVolStatic
5.44×
heavier than its own normal
Short int.Static
12.6%
short interest below 20%
ATRStatic
$2.44
14-session average true range
A checklist, not odds on a return: 4 of 6 usable price conditions have to line up. RSI, the 50-day average and the Bollinger band move with the price you set; the 20-day average traded price, the entry level and the busiest put strike stay fixed. MACD, RVol, Short int. and ATR are context only — they never count toward the total.
See the full case→
Next earnings
—
not on file
Next dividend
No indicated yield
no forward dividend on file