Ionis Pharmaceuticals, Inc. (IONS) — Biotechnology. Numbers-first dossier: valuation, distress risk, calibrated signal.

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IONS earnings history

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Bid — × — AskUpdated Sep 25, 2026 · 12:00 AM ETVol 6.15M · 3-mo avg 3.61M

Ionis Pharmaceuticals, Inc. (IONS)

IONSIonis Pharmaceuticals, Inc.loading…
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QTick signal
0net
2 bull / 2 bear factors · balanced
Bull 4 pts·Bear 4 pts30d
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Market context—Sector read · not on fileCautionBalance sheet · Grey—PCE inflation days · not on fileCautionHeavy selling · 68/100 · as of 2026-09-24
Smart entry
$43.59
basis · low 52w + s1 · as of 2026-09-24
Target exit zone
$59–61
center $60.00 · basis · call wall · as of 2026-09-24
Implied move · 1 wk
±$3.29
7.4% · options-priced
Chart pattern
Death cross
50d below 200d · bearish structure
Pullback risk
Elevated
1.08× the norm · 86% saw a ≥10% dip · 63d · tape state: hot selling
Chart pattern
Death cross
50d below 200d · bearish structure
Volume vs its own 20-session average1.56×
52-week range$44.20 – $86.74
Below high since 2015-51.8% · $90.90 high
Risk / reward2.44 : 1
Plan stop$38.16
Max pain$52.50 options cluster
RSI 1425.6 oversold
Forensic flags1 review
Earnings multiplen.m. — no profit expected
P/E vs its own pastnot on file
Free cash flow yield-4.4% · burning cash

Last session traded heavier than its own normal. Over the last 20 sessions, 87% of the volume traded on days the stock closed lower.

Entry strategy · 10 triggers

3 of 6 aligned — closing in
RSI 14
✓
25.6
oversold
vs 50-day
✓
$55.23
below the line
Bollinger
●
$39.93
no lower pierce · fires near $38.63
VWAP 20
✓
$51.51
below the rolling VWAP
Entry level
●
$43.59
level below · fires near $44.00
Put wall
●
$40.00
2026-10-16 expiry · chain of 2026-09-24
MACD
Context●
-1.31
below zero · rising toward the flip
RVolStatic
1.56×
heavier than its own normal
Short int.Static
12.8%
short interest below 20%
ATRStatic
$2.72
14-session average true range
A checklist, not odds on a return: 4 of 6 usable price conditions have to line up. RSI, the 50-day average and the Bollinger band move with the price you set; the 20-day average traded price, the entry level and the busiest put strike stay fixed. MACD, RVol, Short int. and ATR are context only — they never count toward the total.
See the full case→
Next earnings
2026-11-04
in 29 sessions
Next dividend
No indicated yield
no forward dividend on file